Elfreth's Alley Museum interprets America's oldest continuously inhabited residential street.
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Betsy Ross House is the colonial home associated with the upholsterer and flag maker Betsy Ross.
Eastern State Penitentiary is a historic prison and museum interpreting the history of American criminal justice.
Wagner Free Institute of Science preserves a Victorian natural history museum and offers free science education.

The Mütter Museum of The College of Physicians of Philadelphia displays historic medical collections, anatomical specimens and instruments.
Academy of Natural Sciences of Drexel University, founded in 1812, is a natural history museum and research institution.
The Franklin Institute is one of the oldest and most visited science museums in the country, home to the Benjamin Franklin National Memorial.
Benjamin Franklin Museum at Franklin Court explores the life, character and legacy of Benjamin Franklin.
The Liberty Bell Center displays the Liberty Bell, an enduring symbol of freedom, in Independence National Historical Park.
Independence Hall is where the Declaration of Independence and the U.S. Constitution were debated and signed, part of Independence National Historical Park.
Weitzman National Museum of American Jewish History explores the history of Jewish people in America.
National Constitution Center on Independence Mall is a museum and civic education center dedicated to the U.S. Constitution.
Museum of the American Revolution tells the story of the Revolution through artifacts, art and immersive galleries, including Washington's war tent.
African American Museum in Philadelphia was the first institution built by a major U.S. city to preserve and interpret African American history and culture.

Philadelphia's Magic Gardens is an immersive mosaic environment and gallery created by artist Isaiah Zagar.
The Fabric Workshop and Museum commissions and exhibits new work by contemporary artists in new materials and media.
Woodmere Art Museum in Chestnut Hill is devoted to the art and artists of Philadelphia.
Institute of Contemporary Art at the University of Pennsylvania presents contemporary art exhibitions free to the public.